Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1564 | Thyroid (non-cancer) | ICEECE2012

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism

Sanchez N Martinez , Varela L. , Martins L. , de Morentin P Martinez , Gallego R. , Vazquez M. , Roa J. , Gandara M. , Schoenmakers E. , Nogueiras R. , Chatterjee K. , Sempere M. Tena , Dieguez C. , Lopez M.

Hyperthyroid rats and humans exhibit increased energy expenditure and marked hyperphagia. Recent evidence has pointed that alterations of thermogenesis linked to hyperthyroidism are associated to dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear.Objective: The aim of our study was to assess if alterations in feeding in hyperthyroidism are asso...